It is of great significance for the ecological environmental protection and sustainable development by assessing the habitat quality changes caused by land use and revealing the impact from human activities on the ecological environment.This study analyzed the characteristics of the spatial-temporal variation of habitat quality and the evolution of key point in China in 2000,2005,2010 and 2018 based on the current land use data by applying the InVEST model,the kernel density estimation method and the standard deviation ellipse.The results showed that 1) The overall spatial pattern of habitat quality in China from 2000 to 2018 was relatively stable,and the habitat quality in urban-rural junction area reduced most severely;2) In study period,the habitat quality changes experienced the stage of active-relatively cool-active,and the active area shifted from the southeast coast to the inland.The Yangtze River Basin became a new active area of habitat quality changes,reflecting the difference in the degree of human impact on the natural environment in different periods;3)The core point of habitat quality changes from 2000 to 2018 experienced a repeated process of first to the southeast and then to the northwest.The main direction of change was northwest-southeast.