【Objective】 To investigate the fundamental composition,floristic characteristics,origin and evolution of medicinal seed plants in the desert region of Inner Mongolia.【Method】 The floristic characteristics of medicinal seed plants in the desert region of Inner Mongolia were statistically analyzed following the basic principles of floristic geography. This analysis involved consulting data and conducting field investigations.【Result】The desert region of Inner Mongolia is home to 285 species of medicinal seed plants belonging to 190 genera and 66 families. Within this group,279 species of angiosperms,distributed across 186 genera and 63 families . The representative families are Elaeagnaceae,Typhoidaceae,Ephedraceae,Orobanchaceae,Tamaricaceae,and Sparganaceae. Dominant families in- clude 10 or more species. The flora is primarily associated with the temperate zone at the genus level,and at the fam- ily level,it has a global distribution.【Conclusion】 Medicinal plants in the Inner Mongolia are dominated by angio- sperms with most being xerophytic herbs and shrubs displaying strong adaptability to the harsh desert environment. There are relatively few hygrophytes or marsh plants in this region. Due to the challenging living conditions in desert areas,the diversity of plant species is limited. The flora exhibits a distinct temperate character and can be considered a native region with extensive geographical connections,sharing a certain kinship with tropical regions.