【Objective】 The study was carried out to explore the dynamic change pattern of vegetation in QinghaiLake Basin and its response to climate change and human activities.【Method】 Based on MOD13Q1 remote sensingdata and meteorological data, this paper analyzed the spatial and temporal variation characteristics and driving forces of vegetation coverage in the basin from 2001 to 2019 by means of trend analysis, multiple regression residual analy-sis and partial correlation analysis.【Result】 The results showed that:(1) The growth rate of fractional vegetationcover (FVC) in Qinghai Lake Basin from 2001 to 2019 was 2. 1%/10 a,showing a significant upward trend (P<0. 05). The improved area of FVC was about 1. 21×104 km2,accounting for 48. 77% of the total area.(2) The con-tribution rates of climate change and human activities to vegetation cover change were 57. 83% and 41. 52%,respec-tively.(3) The area ratios of precipitation and temperature significantly positively correlated with FVC changes were7. 93% and 4. 15%,respectively.【Conclusion】 The analysis shows that the overall improvement of FVC in the Qing-hai Lake Basin in the past 19 a is significant, and the significant improvement areas are mainly distributed in the west-ern part of the basin and the northern bank of Qinghai Lake. Climate change is the dominant factor of FVC change inthe basin,but human activities have a significant inhibitory effect on the local area. Precipitation has a higher influenceon FVC changes in the basin,and local FVC changes respond more strongly to temperature.